2018-06-29 17:26:392025-05-24 08:49:36
description
L-threonylcarbamoyl-AMP synthase, biosynthesis of the hypermodified base threonylcarbamoyladenosine (t(6)A) (together with TsaB-TsaD-TsaE)
L-threonylcarbamoyl-AMP synthase, biosynthesis of the hypermodified base threonylcarbamoyladenosine (t(6)A) (together with [[protein|TsaB]]-[[protein|TsaD]]-[[protein|TsaE]])
locus
BSU36950
BSU_36950
geneLength
1038
1041
outlinks
bsu
BSU36950
BSU_36950
Gene
Phenotypes of a mutant
restores viability of a ''[[gene|smc]]'' mutant on rich medium due to the induction of a [SW|stringent response] [Pubmed|26539825]
poor growth [pubmed|28189581]
poorly transformable [pubmed|28189581]
restores viability of a ''[[gene|smc]]'' mutant on rich medium due to the induction of a [SW|stringent response] [Pubmed|26539825]
The protein
Catalyzed reaction/ biological activity
conversion of L-threonine, bicarbonate/CO2 and ATP to give the intermediate L-threonylcarbamoyl-AMP (TC-AMP) and pyrophosphate as products [Pubmed|23072323]
biosynthesis of the hypermodified base threonylcarbamoyladenosine (t(6)A), a universal modification found at position 37 of ANN decoding tRNAs, which imparts a unique structure to the anticodon loop enhancing its binding to ribosomes in vitro (shown for the corresponding ''E. coli'' protein YrdC) [Pubmed|19287007]
conversion of L-threonine, bicarbonate/CO2 and ATP to give the intermediate L-threonylcarbamoyl-AMP (TC-AMP) and pyrophosphate as products [Pubmed|23072323]
biosynthesis of the hypermodified base threonylcarbamoyladenosine (t(6)A), a universal modification found at position 37 of ANN decoding tRNAs, which imparts a unique structure to the anticodon loop enhancing its binding to ribosomes in vitro (shown for the corresponding ''E. coli'' protein YrdC) [Pubmed|19287007]
ATP + hydrogencarbonate + L-threonine --> diphosphate + H2O + L-threonylcarbamoyladenylate (according to UniProt)
The protein
Protein family
SUA5 family (according to Swiss-Prot)
SUA5 family (single member, according to UniProt)
References
The protein
Paralogous protein(s)
[[this]]
The protein
[SW|Domains]
YrdC-like domains (aa 18-205) (according to UniProt)